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For the cell-cycle analysis, scc-9 cells were seeded, serum starved for 48 hours, and treated with orlistat or transfected with fasn-specific sirnas in dmem f-12 supplemented with 10 fbs.
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The use of orlistat has been associated with several mild-to-moderate gastrointestinal adverse effects, such as oily stools, diarrhea, abdominal pain, and fecal spotting, which generally decrease in frequency with ongoing orlistat treatment.
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We found 426 hypoglycaemia events in the orlistat group and 300 in the placebo group and an average of 2.
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Only trace amounts of orlistat are absorbed systemically and the drug remains almost entirely in the gut lumen 9 .
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